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11:00 VENDREDI 26 OCTOBRE, 2011
ENS LYON -­‐   Site Monod* -­‐  Salle des Thèses

Modular Biomaterials for directed delivery of Therapeutics: Applications to Vaccine Design and
Immunotherapy

Prof. Tarek M. FAHMY, PhD Departments of Biomedical and Chemical Engineering Yale University, New Haven Connecticut, USA

www.fahmylab.org

The concept of targeted drugs is not new, but dates back to 1906 when Ehrlich first postulated  the
‘magic bullet’.  The challenge  for the clinic has been three fold:  finding  the proper target for
a particular  disease state; finding a drug that effectively treats this disease; and finding a
means of carrying the drug in a stable form to specific sites in the body.  Nanoparticles are
potentially useful as carriers of active drugs, antigens and biological therapeutics and, when
coupled with targeting ligands, may fulfill many attributes of ‘magic bullets.’ This talk focuses
on targeted agent delivery to immune system cells.  Particularly  challenging  cases are the tumor
microenvironment  or sites of inflammation.  Both areas thwart conventional immunotherapy through
multiple  immunologic  mechanisms.    Nanomaterials  can  be  engineered  in  ways  that  can
overcome  these mechanisms.   An  attractive  feature  of  these  synthetic  systems  is  that  
they  can  be  ‘tuned’  in  predictable, designable  ways to optimize  immune  function;  
ultimately  orchestrating  the magnitude  and direction  of an immune   response.   Here   we   
present   current   biomaterial   designs   for   induction   of   therapeutic   immune
responses in cancer and autoimmune disease.

Contact : Brian B. RUDKIN (bbrudkin@ens-­lyon.fr)

Programme

Public concerné : chercheurs

Type d'évenement : seminaire